Reds Opening Day 2025 Dates And Times. Cincinnati — the reds announced their entire schedule for the 2025 season on thursday afternoon. The cincinnati reds will once again host the first series of the season.

The cincinnati reds will play the san francisco giants on march 27, 2025, at great american ball park on opening day in cincinnati. Opening day is on thursday, march 27 against the san francisco giants.